Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design
نویسندگان
چکیده
منابع مشابه
Structural plasticity of the cyclic-cystine-knot framework: implications for biological activity and drug design.
The cyclotide family of plant proteins is of interest because of their unique topology, which combines a head-to-tail cyclic backbone with an embedded cystine knot, and because their remarkable chemical and biological properties make them ideal candidates as grafting templates for biologically active peptide epitopes. The present study describes the first steps towards exploiting the cyclotide ...
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Cystine knot of the gonadotropin alpha subunit is critical for intracellular behavior but not for in vitro biological activity.
The common alpha subunit of glycoprotein hormones contains five disulfide bonds. Based on the published crystal structure, the assignments are 7-31, 59-87, 10-60, 28-82, and 32-84; the last three comprise the cystine knot, a structure also seen in a variety of growth factors. Previously, we demonstrated that the efficiency of secretion and the ability to form heterodimers by alpha subunits bear...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2006
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20051691